WILMINGTON, MA — The Wilmington Board of Selectmen will interview the finalists in the town’s search for its Finance Director/Town Accountant on Tuesday, April 16, 2019 at 7pm at Town Hall.The two finalists are Hayley S. Green, CPA — who currently serves as the Town Accountant/Assistant Finance Director for the Town of Andover — and Bryan Perry, CPA — who currently serves as the City Auditor for Lowell.Green will interview at 7pm. Perry will interview at 8:15pm. Each interview is scheduled to last an hour. These interviews will be open to the public.As described in a memo written by Town Accountant Mike Morris and provided to the Selectmen on Monday night, the town received 10 applicants for the job opening.The screening committee — which consisted of the soon-to-be-retiring Town Account Mike Morris, Town Manager Jeff Hull, Assistant Town Manager Kerry Colburn-Dion, and Selectman Jonathan Eaton — interviewed three applicants and decided to bring forth two finalists — Green and Perry — for the Selectmen to interview.Town Accountant Mike Morris, who has served the town for more than 30 years, has announced his intention to retire in early July.Selectmen took the opportunity to tweak the town’s financial management structure, turning the Town Accountant position into a Finance Director/Town Accountant position.The new position is responsible to the Town Manager and Board of Selectmen, serves as Town Accountant and Chief Financial Officer, and oversees the Town’s financial activities which include accounting, assessing, collections, treasury, financial systems and purchasing. The position advises the Town Manager on revenue projections, serves as the Town Manager’s technical advisor on departmental budgets and management, and has oversight of the preparation of the Town’s annual operating and capital budgets.Like Wilmington Apple on Facebook. Follow Wilmington Apple on Twitter. Follow Wilmington Apple on Instagram. Subscribe to Wilmington Apple’s daily email newsletter HERE. Got a comment, question, photo, press release, or news tip? Email firstname.lastname@example.org. Share this:TwitterFacebookLike this:Like Loading… RelatedSELECTMEN NEWS: Board To Interview 2 Finalists For Finance Director/Town Accountant On Wednesday NightIn “Government”SELECTMEN NEWS: New Finance Director & Town Accountant AppointedIn “Government”5 QUICK QUESTIONS with Wilmington’s New Finance Director Bryan PerryIn “5 Quick Questions”
SUVs Luxury cars Future Cars Enlarge ImageTalk about getting off to a good start. Andrew Krok/Roadshow When a car is more efficient, less expensive and more powerful than its also-new competition, that sounds like a pretty good start. Lincoln should have plenty to celebrate this week, then, now that fuel economy numbers are out for the base-trim 2020 Aviator.According to newly published EPA figures, the 2020 Lincoln Aviator in base, rear-wheel drive trim is rated at 18 miles per gallon city, 26 mpg highway and 21 combined. It’s still more expensive than your average vehicle, which is why the EPA estimates that Aviator owners will spend $2,250 more in fuel costs over five years when compared to the average new car.That’s not bad, considering its engine is a 3.0-liter, twin-turbocharged V6 that puts out 400 horsepower and 400 pound-feet of torque. Its starting price is $52,195, which includes destination, and adding AWD will tack another $2,500 on to the price, likely lowering fuel economy a bit in the process.Let’s compare that to the Aviator’s also-new competitor, the 2020 Cadillac XT6. It’s rated just a smidge lower than the Aviator at 18 mpg city, 25 highway and 20 combined. Yet, it’s a more expensive proposition at $53,690 including destination. Front-wheel drive is standard, as opposed to the Aviator’s standard RWD. Most surprising, though, is the huge output delta between these two — the XT6’s naturally-aspirated 3.6-liter V6 only musters 310 hp and 271 lb-ft. Yikes. The XT6 is also down a cog in its automatic transmission, packing 9 compared to the Aviator’s 10.The 2020 Cadillac XT6 goes on sale this summer, around the same time the Aviator does. It’ll be interesting to see how both perform, not only against each other, but against the greater midsize luxury SUV segment. 1:26 Lincoln Cadillac More From Roadshow Review • 2019 Lincoln Navigator: Bigger and better More about 2019 Lincoln Navigator 2020 Lincoln Aviator takes off at LA Auto Show 58 Photos 2020 Lincoln Aviator plug-in hybrid first drive: This changes everything Tags 2020 Lincoln Aviator first drive: Stylish SUV takes flight with smart tech Share your voice 1 2020 Cadillac XT6 first drive: Sometimes ‘more’ is more Comment The sky’s the limit in the 2020 Lincoln Aviator Now playing: Watch this: Lincoln Cadillac
(PhysOrg.com) — Two research groups working independently have come up with two different ways to use whole-genome sequencing to follow the path bacteria take in developing resistance to anti-bacterial drugs. Such research could prove useful in figuring out ways to stop the evolutionary process, thereby safeguarding current anti-bacterial agents for future patients. Both groups have published papers describing their work in Nature Genetics. The first group has found a way to actually monitor the evolution of the E. coli bacteria over several generations as it’s exposed to three types of anti-bacterial agents. The second group has figured out a way to follow mutations in bacteria that occur after anti-bacterial agents have been discontinued. More information:  Whole-genome sequencing of rifampicin-resistant Mycobacterium tuberculosis strains identifies compensatory mutations in RNA polymerase genes, Nature Genetics (2011) doi:10.1038/ng.1038AbstractEpidemics of drug-resistant bacteria emerge worldwide, even as resistant strains frequently have reduced fitness compared to their drug-susceptible counterparts. Data from model systems suggest that the fitness cost of antimicrobial resistance can be reduced by compensatory mutations; however, there is limited evidence that compensatory evolution has any significant role in the success of drug-resistant bacteria in human populations. Here we describe a set of compensatory mutations in the RNA polymerase genes of rifampicin-resistant M. tuberculosis, the etiologic agent of human tuberculosis (TB). M. tuberculosis strains harboring these compensatory mutations showed a high competitive fitness in vitro. Moreover, these mutations were associated with high fitness in vivo, as determined by examining their relative clinical frequency across patient populations. Of note, in countries with the world’s highest incidence of multidrug-resistant (MDR) TB, more than 30% of MDR clinical isolates had this form of mutation. Our findings support a role for compensatory evolution in the global epidemics of MDR TB.Evolutionary paths to antibiotic resistance under dynamically sustained drug selection, Nature Genetics (2011) doi:10.1038/ng.1034AbstractAntibiotic resistance can evolve through the sequential accumulation of multiple mutations. To study such gradual evolution, we developed a selection device, the ‘morbidostat’, that continuously monitors bacterial growth and dynamically regulates drug concentrations, such that the evolving population is constantly challenged. We analyzed the evolution of resistance in Escherichia coli under selection with single drugs, including chloramphenicol, doxycycline and trimethoprim. Over a period of ~20 days, resistance levels increased dramatically, with parallel populations showing similar phenotypic trajectories. Whole-genome sequencing of the evolved strains identified mutations both specific to resistance to a particular drug and shared in resistance to multiple drugs. Chloramphenicol and doxycycline resistance evolved smoothly through diverse combinations of mutations in genes involved in translation, transcription and transport. In contrast, trimethoprim resistance evolved in a stepwise manner, through mutations restricted to the gene encoding the enzyme dihydrofolate reductase (DHFR). Sequencing of DHFR over the time course of the experiment showed that parallel populations evolved similar mutations and acquired them in a similar order. Citation: Researchers use whole-genome sequencing to monitor evolution of drug resistance in bacteria (2011, December 19) retrieved 18 August 2019 from https://phys.org/news/2011-12-whole-genome-sequencing-evolution-drug-resistance.html © 2011 PhysOrg.com Explore further The first group, all working out of Harvard University, created what they call a “morbidostat”; a computer controlled environment that reads signs from a bacteria culture to asses its degree of happiness with its surroundings, then tweaks it just a little bit to make it unhappy. Bacteria that are happy don’t need to adapt, thus, to cause them to evolve, three types of antibacterial agents were introduced into the morbidostat along with the bacteria: chloramphenicol, doxycyclin, and trimethoprim. To see what evolutionary changes were occurring, the team took regular samples and studied them using whole-genome sequencing. Using this technique the team found they could actually watch the bacteria evolve into resistant strains. But of particular note, they found that at least when exposed to trimethoprim, Escherichia coli evolves in very predictable ways, a bit of knowledge that could help doctors stay one step ahead of such changes when treating patients by predicting them before they are able to occur.Just as interesting is the study undertaken by the second group; a team made up of an international group of researchers. Here the team wanted to know what goes on with bacteria that are subjected to anti-bacterial agents, after the treatment is stopped. Do they stop evolving, or do they keep on doing so as a means of responding to the effects of the drugs?Prior research has already shown that most often drug-resistant bacteria for some reason don’t grow as quickly as those that aren’t resistant when in an environment free of antibiotics, which should mean resistant strains should have transmission rates that are lower. Unfortunately, this is not always the case as some resistant strains of some types of bacteria have shown an ability to transmit just as quickly as their non-resistant brethren. To find out why this is, the team analyzed both types of strains using whole-genome sequencing to find out exactly what was going with different strains of M. tuberculosis.The team found that those strains that were both resistant and able to transmit at the same rates as the non-resistant group had developed two types of mutations. The first was, obviously, the changes that had come about that had made them resistant. The second change was the surprise; the bacteria samples had actually evolved in a way that allowed them to regain a high transmission rate, which showed they had continued to evolve after the anti-bacterial drug had been stopped, this time, to get back something it had lost due to the drug.Taken together, the studies show that by using whole-genome sequencing, researchers are moving ever closer to fully understanding how bacteria mutate and evolve to make themselves resistant to anti-bacterial agents. The hope is that once the entire process is fully understood, new ways to prevent it from happening can be developed. Drug-resistant bacteria can be controlled This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
Kolkata: Thousands of people from neighbouring states are getting benefits of various health schemes initiated by the Bengal government.Chief Minister Mamata Banerjee’s dream projects of providing free-of-cost health services in all state-run hospitals and medical colleges, have already become a great success with a large number of people availing free treatment at the hospitals. Now, it has been found that many patients from neighbouring states and countries are also benefitting from the health schemes.The success of the project has gone to the extent where a large number of people are coming to the city to undergo critical surgeries at various hospitals, thereby availing the benefits of the health schemes started by the Mamata Banerjee government. According to a senior Health department official, people from outside the state are reaping the benefits of the projects and many of these patients are undergoing critical surgeries at various state-run medical colleges in the city, free-of-cost.A sizeable number of patients are from Bangladesh. In most of the cases, the state Health department is clueless about the whereabouts of these patients coming from outside, as they show themselves to be local residents. After the disease is cured, the patients go back to their respective native places. This in turn is creating a pressure on the state government.”We cannot stop a patient from outside from being treated at a government hospital free-of-cost, only because he/she is not a resident of the state. Thus, many outside patients are found to be getting the benefits of various health schemes of the state,” a senior official of the Health department said.It has been found that in many cases, the patients mention the address of their local relatives, where they stay during their visit to the state. Most of these outside patients are from Jharkhand and Bihar, among other states. A large number of people from Bangladesh and Nepal also visit the hospitals.
Kolkata: The first Primary Health Centre (PHC) in New Town will be opened shortly.The centre will be manned by a specialised doctor and the facility will be expanded over a period of time. It may be mentioned that New Town is coming up as a medical hub and many private players have set up their hospitals and medical centres in the area. They are also treating every type of disease including cancer. However, the need for setting up a state-run institution was urgently felt as a part of the expansion of the net of state-run health establishments. Also Read – Bose & Gandhi: More similar than apart, says Sugata BoseIt may be recalled that availing treatment in a state-run medical establishment in Bengal has become completely free. Chief Minister Mamata Banerjee has also said that to get the best quality treatment, people from neighbouring states and countries are coming to Bengal. Bengal is the only state in the country where heart transplantation and kidney transplantation are done free of cost in the state-run hospitals. In this backdrop, the PHC in New Town is also expected to provide quality treatment to the patients, free of cost.
Earlier this month, AKQA, a global innovation agency, introduced a new outdoor sport called Speedgate, which is created by an AI system built by them. This AI system was trained on more than 400 sports including Rugby, Soccer, and football to form the rules and regulations for Speedgate. In Speedgate, each team has six players consisting of forwards and defenders. The teams playing the game have to score goals by kicking through two consecutive gates. When a player kicks the ball through an X gate, the center gate will unlock the goal gate. After the center gate is unlocked, the team in possession can score by kicking the ball through the end gate in any direction. Here’s a video showing how this game actually works: Developers at AKQA trained a recurrent neural network and a deep convolutional generative adversarial network on over 400 sports. It uses NVIDIA Tesla GPUs for training the neural networks as well as for inferencing. Additionally, the neural network was also trained on 10,400 logos to generate the official Speedgate logo. The model was able to generate over 1,000 different sport concepts. Though many of them were interesting, the team wanted the AI system to come up with a game that was in addition to being fun and easy to understand was also active and accessible. And, Speedgate checked all the boxes for them. Kathryn Webb, AI Practice Lead at AKQA, said, “GPU technology helped us to condense training and generation phases down to a fraction of what they would’ve been. We would not have been able to achieve so many unique ML contributions in the project without that speed. It gave us more time to test, learn and adapt, and ultimately helped to produce the best final result.” Read more in detail, visit AKQA’s official website. Read Next OpenAI Five beats pro Dota 2 players; wins 2-1 against the gamers Google announces Stadia, a cloud-based game streaming service, at GDC 2019 Microsoft announces Game stack with Xbox Live integration to Android and iOS
Posted by Travelweek Group New York City carriage horse breaks free and runs through rush hour traffic Wednesday, May 31, 2017 Share NEW YORK — A New York City carriage horse is safely back in its stable after breaking free and running wild through rush hour traffic.The horse, a 12-year-old mare named Goldie, broke free on Tuesday while being taken back to her stable in the Hell’s Kitchen neighbourhood of Manhattan. Witnesses say Goldie soon went into a full gallop, cutting off cars and running across streets.After running eleven blocks, Goldie returned to her stable on her own. She was not injured.A carriage driver says it wasn’t that big of a deal and tells WNBC-TV that Goldie probably wanted some exercise after a slow day at work. << Previous PostNext Post >>
Share This is the dirtiest spot on an airplane (and it’s not what you think!) << Previous PostNext Post >> Friday, September 1, 2017 Travelweek Group Posted by TORONTO — A new study from Travel Math about the dirtiest places on an airplane will have you reaching for that bottle of hand sanitizer in no time.According to Southern Living, the study took swabs from four different flights and sent them to a lab to be tested. The results, which are an average from those four flights, may surprise you.Shockingly, the most germ-infested spot on an airplane is where you’d place your food. That’s right, the tray table is absolutely ridden with germs! It tested for 2,155 colony-forming units (CFU) of bacteria per square inch. To put this into perspective, coming in as the #2 dirtiest spot is the overhead air vent with a paltry 285 CFU per square inch.The flush button in the lavatory – which many would assume would be the filthiest – actually came in at #3 with 265 CFU per square inch, followed by the seatbelt bucket with 230 CFU per square inch.More news: Honolulu authorities investigate arsons at 3 Waikiki hotels; no injuries reportedThe study also examined airports, and found that the push button on water fountains were cesspools of bacteria, with $1,240 CFU per square inch.So next time you board an airplane, it may be wise to bring your own tablecloth. And don’t forget your hand sanitizer!