Nov 11, 2004 (CIDRAP News) – The outbreak of H5N1 avian influenza in Asia gives the world its first opportunity to prepare a vaccine in advance for a potential pandemic strain of flu, the World Health Organization (WHO) said today as it convened a meeting of vaccine companies and health officials to consider the challenge.Representatives of vaccine manufacturers and government officials from the manufacturers’ countries are meeting at WHO headquarters in Geneva, Switzerland, to discuss how to develop vaccines for pandemic flu.”The current outbreak of H5N1 is a stark warning that conditions are highly favourable for the emergence of a pandemic virus,” the WHO said in a statement on its Web site. “For the first time in history, there is a window of opportunity to consider using a pandemic vaccine in humans at a time when a virus with significant pandemic potential is circulating in large parts of Asia.”The H5N1 strain of avian flu has infected at least 44 people in Asia this year and has killed 32. The virus has not been known to spread from person to person, but experts fear that it could acquire this ability through mutation, potentially leading to a pandemic.The WHO noted that vaccines have never been available during past pandemics, including the last two, in 1957 and 1968, when annual vaccination programs for ordinary flu were fully established. Past pandemic strains were not discovered until they began spreading internationally, the agency said. The viruses spread worldwide in 6 to 8 months, far too short a time to develop and distribute a vaccine.A few companies have begun to develop vaccines for potential pandemic viruses, the WHO said. “However, production capacity for a pandemic vaccine will be vastly inadequate unless other companies engage in vaccine seed development and preparation of batches for clinical testing,” the agency said.The statement said vaccine makers face two major challenges: finding the optimal formulation for a pandemic vaccine through clinical trials, and registering their vaccine with their national drug licensing agency.”Such registration, done with a ‘template’ influenza subtype which will eventually be replaced by the strain actually causing the epidemic, is a condition which every manufacturer must fulfill to produce pandemic vaccine, regardless of when the next pandemic occurs and which strain causes it,” the WHO said.In the United States, Aventis Pasteur Inc. and Chiron Corp. each won a government contract last May to produce 8,000 to 10,000 doses of an H5N1 vaccine based on virus isolated from a Vietnamese patient. The National Institute of Allergy and Infectious Diseases said it would use the vaccines in clinical trials.In September, the Department of Health and Human Services (HHS) awarded a contract to Aventis Pasteur to make 2 million doses of its H5N1 vaccine for about $13 million. HHS officials then said clinical trials would start late this year or early next year.See also:WHO statement about Geneva meetinghttp://www.who.int/csr/disease/influenza/meeting2004_11_08/en/Sep 21, 2004, CIDRAP News story “HHS awards contract for H5N1 avian flu vaccine”May 28, 2004, CIDRAP News story, “NIAID seeks vaccines for H5N1 avian flu”
Other people then catch COVID-19 bytouching these objects or surfaces, then touching their eyes, nose or mouth,said WHO. “Mayroon nang community quarantine sa bayan ngTayasan. All councilors of Tayasan and some [from] Negros Oriental na nakasamaniya sa Councilors League [ay] under quarantine din,” he added. Patient 39 was initially confined atthe Ace Doctors Dumaguete, Inc. hospital. Greenhills was where Patient 5 – whoeventually died a few days before Patient 39 – used to frequent to pray at aprayer hall, according to the Department of Health. He visited Greenhills Shopping Centerin San Juan City flying back to Tayasan on March 1. People can also catch COVID-19 if theybreathe in droplets from a person with COVID-19 who coughs out or exhalesdroplets. This is why it is important to stay more than one meter (three feet)away from a person who is sick, it added. He was considered immune-compromisedas he was a kidney transplantee. He attended a flag-raising ceremony at Tayasanon March 2 and the graduation ceremony of Tayasan elementary students before displayingCOVID-19 symptoms. Negros Oriental governor Noel Degamosaid the 62-year-old councilor, identified by the Department of Health (DOH) asPatient 39, succumbed to the disease at 11:09 a.m. Three of 15 people in the provincesuspected of carrying the virus tested negative, while 264 are being monitored. MANILA – A Negros Oriental towncouncilor, the first confirmed case of coronavirus disease 2019 (COVID-19) inthe Visayas, died yesterday. According to the World HealthOrganization (WHO), people can catch COVID-19 from others who have the virus.The disease can spread from person to person through small droplets from thenose or mouth which are spread when a person with COVID-19 coughs or exhales.These droplets land on objects and surfaces around the person. The most common symptoms of COVID-19are fever, tiredness, and dry cough. Some patients may have aches and pains,nasal congestion, runny nose, sore throat or diarrhea. These symptoms areusually mild and begin gradually. Some people become infected but don’t developany symptoms and don’t feel unwell. Mark Angelo Llosa, chief of Negros OrientalProvincial Hospital where the councilor was confined, said in a separateinterview that the councilor likely had multiple organ failure and was set tobe cremated yesterday. WHO said most people (about 80percent) recover from the disease without needing special treatment. Around oneout of every 6 people who gets COVID-19 becomes seriously ill and developsdifficulty breathing. Older people, and those with underlying medical problemslike high blood pressure, heart problems or diabetes, are more likely todevelop serious illness./PN The patient was a councilor fromTayasan who went to Manila on Feb. 26 to attend the Philippine CouncilorsLeague convention.
Women’s World Cup 2019: Updated group stage results and standings 60 – Vivianne Miedema scored her 60th goal for the Netherlands Women’s team and is now the all-time top goal scorer of @oranjevrouwen. Legendary. #NED pic.twitter.com/ooT1nWyJUw— OptaJohan (@OptaJohan) June 15, 2019Miedema’s first goal came four minutes before halftime.Shanice van de Sanden exchanged passes with Jackie Groenen down the right and picked out the run of Miedema, who sent her diving header away from Annette Ngo Ndom from the edge of the 6-yard box.Netherlands’ lead lasted just 154 seconds, though, as Onguene made the most of some slack defending by heading Raissa Feudjio’s long ball past stranded keeper Sari van Veenendaal and into the empty net.That was the first goal the Netherlands had conceded in 443 minutes of play, but it took less than three minutes of the second half for the Dutch to restore their advantage through Bloodworth’s close-range finish at the second attempt. Vivianne Miedema became the Netherlands’ record scorer in a 3-1 win Saturday over Cameroon, advancing the Dutch to the next round of the Women’s World Cup in France.A last-gasp goal from Jill Roord gave the European champions a narrow 1-0 win over New Zealand in their opening Group E match, and they also had to dig deep against a determined Cameroon. Cameroon, heading for an early exit after losing its second game in a row, was level at halftime as Gabrielle Onguene scored a little over two minutes after Miedema had opened the scoring.But Dominique Bloodworth’s first international goal early in the second half was added to by Miedema’s 60th, taking the Netherlands to six points ahead of its final group outing against Canada, which plays New Zealand in Grenoble later Saturday. Related News Women’s World Cup 2019 preview: What to know, how to watch USA vs. Chile Miedema overtook Manon Melis as her country’s leading scorer five minutes from time with a powerful finish past Ngo Ndom after cutting inside from the left. Key Opta FactsNetherlands scored more than once in a Women’s World Cup match for the first time, while it also registered consecutive wins in the competition for the first time.Cameroon has lost four of its last five matches at the Women’s World Cup (W1), losing three in a row. Cameroon is the fifth African nation to lose three consecutive games in the competition after Equatorial Guinea, Ghana, Ivory Coast and Nigeria.Netherlands has won 13 and lost none of its 16 previous matches against teams from Africa.