San Francisco: To give group on its app a better control over how members engage, instant messaging app Telegram has introduced a new feature called “Slow Mode”. The feature allows a group admin to dictate how often a member could send a message in the group. “When an admin enables Slow Mode in a group, you will only be able to send one message per the interval they choose. A timer will show how long you have to wait before sending your next message,” Telegram wrote in a blog-post on Saturday, Also Read – Swiggy now in 500 Indian cities, targets 100 more this year The feature is aimed at making conversations in the group more orderly, while raising the value of each individual message. Telegram is now letting users set custom titles for group admins like “Meme Queen”. In addition, the app is also going to let users even send “silent messages” to somebody. While the text would appear as a notification, it would not trigger a sound-alert. The feature would let users simply hold the Send button to have any message or media delivered without sound. “This also works in groups, should you get an urgent idea at five in the morning – but not urgent enough to wake up everyone in your work chat,” the post explained. Telegram’s Android’s attachment menu has also been refreshed with larger thumbnails. The app claims to be encrypted from end-to-end and currently has a global user base of over 200 million monthly active users.
Bengaluru: The second day of the Duleep Trophy opener between India Blue and India Green was washed out on Sunday without a ball being bowled due to wet ground conditions owing to heavy overnight showers. Play was called off at 2 pm IST. India Green had reduced India Blue to 112 for 6 in 49 overs on a truncated opening day on Saturday. Lanky Bengal speedster Ishan Porel (3/26) took three wickets including the prized scalp of his former India U-19 teammate Shubman Gill as India Blue found the going tough against India Green’s disciplined bowling display. A total of 49 overs were bowled after India Green captain Faiz Fazal won the toss and elected to field as play started mid-way into the second session. The in-form Ruturaj Gaikwad struck 30 off 63 balls (3X4s, 2X6s) before he was bowled by Tanveer Ul-Haq (2/36).
APTN National NewsIt doesn’t have reserve status so government funding is limited.It doesn’t have many of the things that most Canadians take for granted.But this small Anishinabe community in Quebec is getting some help.Two years ago, the community renovated three houses.It may sound insignificant, but it meant everything.APTN National News reporter Danielle Rochette was recently in the community and files this report.
Qualcomm’s stock is tumbling before the opening bell after a federal judge ruled that the company unlawfully stifled cellphone chip market competition and charged excessive licensing fees.U.S. District Judge Lucy Koh in San Jose, California found Tuesday that Qualcomm violated antitrust law, charging high royalties and squeezing out rivals, according to Wall Street Journal report.Koh ordered Qualcomm to negotiate or renegotiate licensing deals with customers. The company must also license its patents to rival chip makers at fair prices and can’t sign exclusive supply agreements with smartphone makers like Apple that block competitors from access to that market.Qualcomm Inc. must submit to monitoring for the next seven years to make sure it follows the order.Shares are down 12% in premarket trading Wednesday.The Associated Press
Pawel Adamowicz, had been mayor since 1998, and according to Montserrat Feixas Vihe, UNHCR Regional Representative for Central Europe, “he received hate mail for his pro-refugee stance, but did not weaken in his belief that integration – which brings with it new talents, new skills, new colours, new languages, and a new mentality – was a winning proposition for everyone in his city.”According to news reports, the alleged assailant, is a 27-year-old Gdansk native, with a track record of violence, who was released from prison only last month. The UN Refugee Agency, is deeply shocked and saddened to hear that the Mayor of Gdansk, Pawel Adamowicz, has died – UNHCR statementAfter attacking Mr. Adamowicz on stage, in front of hundreds of onlookers, he told the crowd that he held a grudge against the mayor’s former political party, after he was imprisoned in 2014 for violent offences. There is no evidence so far, that his attack on the mayor was politically motivated.There has been an outpouring of grief across Poland following the assassination, with President Andrzej Duda, reportedly describing it as an “evil hard to imagine”. He has declared the day of the mayor’s funeral, a day of national mourning.The UNHCR statement said that agency staff were “deeply shocked and saddened” at the news of the Mayor’s death.Mayor Adamowicz launched the Gdansk “Immigrant Integration Model” after meeting Pope Francis in 2016, a model that has inspired other Polish cities, said UNHCR, adding that “our thoughts are with his family, friends and colleagues.”In February last year, UNHCR published this story about Mr. Adamowicz’s efforts to show “a new kind of solidarity” with migrants and refugees, building on the city’s famous legacy as a birthplace of the struggle to throw off Communist dictatorship.“For me, it is all about the moral arguments,” he told the agency, adding that the integration model, which was subsequently taken up by other cities in Poland, needed to be established.“Most important are our Christian values, the humanitarian obligation to help people. I felt it was up to us to take a lead,” he said.
Violence on the rise in Darfur following Sudan military takeover, but UN-AU peacekeeping mission maintains ‘robust posture’ Security across the volatile Darfur region of Sudan has deteriorated since last week’s military takeover in Khartoum, the UN Security Council heard on Wednesday, but the peacekeeping mission in Darfur has “remained vigilant” in the face of rising violence.Jeremiah Mamabolo, Joint Special Representative for hybrid mission UNAMID, updated members on events since the ousting of former president of 30 years, Omar al-Bashir, with news reports suggesting on Wednesday that he had now been transferred to prison.Full story here.Libya: Heavy shelling and civilian deaths ‘blatant violation’ of international law – UN envoy A “toxic flood of electric and electronic waste” that is growing by the day across the world, should be urgently converted into a source of decent work, that can also protect populations from its harmful effects, the United Nations labour agency said on Wednesday. Governments, workers and employer organizations reached agreement at a meeting of the International Labour Organization (ILO) in Geneva, urging that “at all levels”, countries should look to increase and invest in better waste management infrastructure and systems to deal with “the rapidly growing flows of e-waste in ways that advance decent work”. “Protect and empower children online”: UN human rights expert calls for global efforts Heavy rains and flooding in the Islamic Republic of Iran have left more than two million people in need of immediate humanitarian assistance, including refugees, the UN refugee agency, UNHCR, said on Wednesday.A planeload of essential aid items from the agency landed last week in Tehran, while supplies from existing stocks inside Iran, were handed over to authorities, who are battling previously unseen levels of flooding in parts of the country.UNHCR’s assistance includes family tents, sleeping mats, blankets and kitchen equipment.Highlighting the fact that “Iran has hosted millions of refugees for 40 years”, UNHCR’s Director for Asia and the Pacific, Indrika Ratwatte, called on the international community to support the country, “as it faces one of the worst natural disasters in decades”.According to government estimates, some 78 people have lost their lives, over 1,000 are reported injured and about 500,000 people have been displaced, since mid-March.Turn toxic e-waste into a source of ‘decent work’, UN labour agency urges Heavy shelling overnight on Tuesday which hit a densely-populated neighbourhood of Libya’s capital, Tripoli, was condemned “in the strongest terms” by the head of the UN Mission there, after “scores” of civilians were reportedly killed and injured.“Horrible night of random shelling of residential areas”, tweeted UN Special Representative Ghassan Salame on Wednesday, after the Abu Slim district was hit. “For the sake of 3 million civilians living in Greater Tripoli, these attacks should stop. NOW!” Read more here.’Grave concern’ over failure of Yemeni Government and Houthis to implement Stockholm agreementThe members of the Security Council expressed their “grave concern” on Wedneday night, that four months after the agreements reached by the Government of Yemen and the Houthi rebel leadership in Stockholm to stop the fighting in and around the key port city of Hudaydah, “those agreements have not yet been implemented.” Council members also underlined their full support for the Special Envoy of the Secretary-General for Yemen, Martin Griffiths, who led the UN-backed talks that led to last December’s accords in Sweden, and the Chair of the Redeployment Coordination Committee (RCC) in Hudaydah, welcoming “their tireless efforts to support implementation of the Stockholm Agreement.”The statement “welcomed the agreement by the Government of Yemen and the Houthis to the Concept of Operations for Phase 1 of redeployments under the Hodeidah Agreement.”They called on both parties to engage constructively with the Special Envoy and the Chair of the RCC to swiftly agree on local security force arrangements and the Concept of Operations for Phase 2 of redeployments, and noted that “bureaucratic impediments, including at a local level, continued to hamper the UN’s ability to operate effectively”.Members “reiterated their concern about the continued deterioration of the humanitarian situation across Yemen” and encouraged the international community to fully support the 2019 UN Humanitarian Response Plan. They urged all parties to “facilitate the rapid, safe and unhindered access for humanitarian personnel and supplies into and across all areas of Yemen, as well as the rapid and sustained access to humanitarian facilities, including food storage facilities and hospitals.”UN refugee agency stepping up support for Iran’s flood-hit communities The independent UN human rights expert on privacy, Joe Cannataci, has called for coordinated global efforts to simultaneously protect and empower children as they use the internet.Aiming to improve safeguards to protect children’s privacy worldwide, Mr. Cannataci has initiated a two-year programme, including public consultations, with a view to creating a set of recommendations focusing on protection and protocol while children are online.The recommendations will be presented to the UN Human Rights Council in 2021.Mr. Cannataci welcomed recent developments in the United Kingdom, including draft legislation published last week on reducing harm to children online, and the start of a consultation process to establish a new code for ‘Age Appropriate Design’.Adding that he “wants to hear first-hand” from corporations like Google, Apple, Facebook, Microsoft, Amazon, and Twitter, over the feasibility of new guidelines, the UN Special Rapporteur encouraged all stakeholders to contribute to the ongoing consultation exercises.
Mr Trump’s travel ban has led to protests(BBC) A US appeals court has upheld a decision blocking President Trump’s revised “travel ban” on people from six mainly Muslim nations.A lower court had issued the injunction on the grounds that the ban was discriminatory after a challenge by the state of Hawaii.The 90-day ban was to apply to people from Iran, Libya, Syria, Somalia, Sudan and Yemen.It also called for a 120-day ban on all refugees.The Ninth US Circuit Court of Appeals in San Francisco was reviewing a March ruling by a Hawaii-based federal judge that blocked parts of Mr Trump’s order.It followed another ruling in May by a different court, the Fourth US Circuit Court of Appeals in Richmond, Virginia, that upheld a Maryland judge’s ruling that also blocked parts of Mr Trump’s revised ban.Earlier this month the Trump administration filed an emergency request with the Supreme Court to block the Hawaii and Richmond rulings and revive the ban. Share this:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window)RelatedTrump administration asks Supreme Court to revive travel banJune 2, 2017In “World”Trump loses appeal court bid to reinstate travel banFebruary 10, 2017In “World”Trump vows to appeal against travel ban ruling to Supreme CourtMarch 16, 2017In “World”
When the Wii Mini first leaked it looked to be a great update to the Wii console design. It was smaller, used bold new colors, and shipped with both remotes for under $100. But then we started hearing about the features, or lack thereof.In order to ship a $99.99 console Nintendo has cut a number of corners. The Wii Mini is no longer backwards compatible with Gamecube games and doesn’t include the ports for connecting a Gamecube controller. It doesn’t have access to the Internet, so you won’t be downloading any games, and it’s limited in availability to gamers in Canada.Now another missing feature is sure to put even more gamers off ever wanting to own a Wii Mini. Apparently the revised Wii doesn’t have an SD Card slot, meaning you can’t transfer your saves or games on or off the machine.With that being the case, the Wii Mini is not a console to be recommended over the Wii, and a machine most are probably glad isn’t being released for sale in their country now. It’s just too limited to be considered worth the investment.I have to wonder why Nintendo decided the Wii Mini was a good idea. You can pick up a Wii for around $160 (with a game), so the Wii Mini only saves you $60 and doesn’t ship with a game. And look at what you lose for that $60 in terms of the features and associated experience. Nintendo is also pushing the Wii Mini or the Wii U in Canada, with the Wii Mini being seen as the perfect platform just for Wii games. But is that really the case? You can’t access all Wii games on the Wii Mini, and your data is locked down to the machine forever.Canadians will be able to buy a Wii Mini from December 7, but I’d suggest anyone wanting Nintendo’s last-gen console this Christmas pick up the Wii instead. The feature set makes the extra you’ll spend more than worth it.via NintendoWorldReport
The ever-deepening economic crisis and the increasing dire financial straits of his own business prompted a 44-year-old Glyfada boutique owner to turn robber and start terrorising the suburbs of southeast Attica, all along the coast from Nea Smyrni to Voula, Alimos and Vari. In his brief but busy career as an outlaw, the 44-year-old carried out a total of 26 armed robberies, of which five were carried out last Saturday in his own neighbourhood of Glyfada, all on the same day. His victims included corner shops, state lottery and football pool betting agencies, hotels, fastfood restaurants, souvlaki shops, supermarkets and even passers by. He was finally caught this week in Glyfada by officers from the local police department, based on the report filed by a doctor that was held up in by the suspect in his surgery and robbed of 300 euro on Monday. In statements to police, the suspect said that he turned to robbery after his shop ran into difficulties. During a search of the suspect’s car and his shop in Glyfada, police found a replica handgun, eight CO2-powered pellets, four mobile phones, a full-face hood, three pairs of gloves, two screwdrivers, a pair of pliers and another person’s ATM card. The suspect was led before an Athens public prosecutor to be formally charged. Facebook Twitter: @NeosKosmos Instagram
Une éruption volcanique spectaculaire en République démocratique du Congo Dimanche dernier, le volcan Nyamulagira situé à l’est de la République démocratique du Congo est entré en éruption. L’explosion de lave quand bien même impressionnante par son envergure n’a engendré aucun danger direct pour les populations vivant à proximité. Tout a commencé le dimanche 6 novembre, dans le parc national des Virunga, situé à 40 kilomètres de la ville Goma, à l’est de la République démocratique du Congo. En fin d’après midi, Luanne Cadd, directeur en charge de la communication du parc reçoit un appel le prévenant d’une situation inhabituelle. Des bruits, similaires à des coups de feu perturbent la tranquillité habituelle de la réserve naturelle. Quelques instants plus tard, commence l’éruption remarquable du volcan Nyamulagira…”Selon nos instruments, le volcan est entré en éruption vers 17h00. Une fissure est apparue sur le flanc et une fontaine de lave accompagnée de scories, de fumée, de cendres volcaniques a jailli”, indique à l’AFP Dieudonné Wafula, vulcanologue et chercheur au Centre de recherche en sciences naturelles. Pour l’heure il est encore impossible de savoir combien de temps restera réveillé Nyamulagira. Selon les experts, l’éruption pourrait se poursuivre pendant des semaines voire des mois. Luanne Cadd, encore sur place, rapporte ses impressions au National Geographic : “Ce qui est assez impressionnant c’est la lumière qui émane de l’explosion, la façon dont elle éclaire le ciel avec une lueur rouge, et le son. Nous pouvons entendre le grondement sourd du volcan, surtout la nuit dans nos tentes”. Un fascinant spectacle naturel que la responsable qualifie à justes termes de “fontaine monstrueuse”.Une menace pour la biodiversité du parcÀ lire aussiLe Kilimandjaro, un volcan dormant caché dans la plus haute montagne d’AfriquePour l’heure, l’éruption ne présente aucun danger direct pour les populations. Toutefois, la lave qui s’écoule vers le parc constitue une menace pour l’ensemble de sa biodiversité. La réserve naturelle, classée au patrimoine de l’Humanité par l’Unesco abrite en effet diverses espèces de reptiles, d’oiseaux et de mammifères, dont une petite population de gorilles des plaines, particulièrement menacée d’extinction. Selon Dieudonné Wafula, le danger réside également dans les scories et les cendres volcaniques emportées par le vent et pouvant constituer une source de pollution des eaux et de contamination des pâturages. Nyamulagira, le volcan considéré comme le plus actif du continent africain, se réveille généralement tous les deux ans. Le cratère situé à une altitude de près de 3.000 mètres est entré en éruption plus de 40 fois dont la plus violente s’est déroulée en 1938. Les dernières en date remontent à janvier 2010, novembre 2006 et mai 2004. Découvrez les images de l’impressionnante éruption sur MaxisciencesLe 9 novembre 2011 à 14:09 • Maxime Lambert
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Real Madrid’s Gareth Bale has admitted that he is open towards the prospect of playing in the Chinese Super League, amid speculation that he is set to move to another club in the summerSince arriving at Real, back in 2013, Bale has struggled to maintain his place in the starting 11 due to a set of recurring injury and fitness issues. The Welshman has found himself on the fringes under Zinedine Zidane this season and has struggled to find any consistency.Manchester United have been linked with Bale since last summer with Jose Mourinho having admitted that he is an admirer of the 28 year-old’s.A unnamed club in the Chinese Super League reportedly made a €130m bid for Bale last week and the winger, who is currently participating for Wales in the China Cup, has revealed that he finds the prospect of playing in China appealing.“It’s a great country with great people,” said Bale, according to Football365.Fati and Suarez shine against Valencia at Camp Nou Tomás Pavel Ibarra Meda – September 15, 2019 With a mesmerizing first half from Ansu Fati and a brace from Luis Suarez in the second half, Barcelona demolished Valencia at Camp Nou.Valencia…“In terms of the future I’m not too sure, I haven’t really looked that far to be honest.“Whenever I come to China we always have such an amazing reception from the Chinese fans. They’ve been very welcoming to all of us, not just me.“They look after us really well. But I’m sure that if I ever did come I’ll be looked after very well.”Bale recently became the record goalscorer for Wales after netting a hat-trick in their 6-0 win over China. Currently Ryan Giggs’ side are preparing to face Uruguay in the final of the China Cup.
Everton winger Ademola Lookman insists everyone has a different scenario and, therefore, can’t be guaranteed to emulate the successes of others in the BundesligaThe 21-year-old spent the latter part of last season on loan at RB Leipzig and impressed with five goals and four assists in 11 Bundesliga appearances.Since then, the likes of English youngsters Jadon Sancho and Reiss Nelson have starred in the German top flight at Borussia Dortmund and Hoffenheim respectively.While, Chelsea assistant coach Gianfranco Zola confirmed Bayern Munich’s strong interest in young star Callum Hudson-Odoi.“Everyone’s scenario is different, all our situations are different,” said Lookman, according to Liverpool Echo.Crouch: Liverpool could beat Man United to Jadon Sancho Andrew Smyth – September 14, 2019 Peter Crouch wouldn’t be surprised to see Jadon Sancho end up at Liverpool one day instead of his long-term pursuers Manchester United.“So I think it is about the experience because wherever you go you can say you are going to play, but you have to prove it.“It is for experience, learning new football, learning a new style, just being around it.“It was different football [in Germany], but I wouldn’t say it was daunting. It was just another experience, take it in your stride and get used to it.”Since returning to Everton for this season, Lookman has made just the one start in 11 Premier League appearances.
The extreme heatwave that recently saw temperatures soar across India was a stark reminder that this region is one of the most vulnerable to the impacts of climate change. As countries start to declare climate emergencies, following the urgent call for decarbonisation in last year’s Intergovernmental Panel on Climate Change report, it is now, more than ever, in the hands of companies and governments to find solutions. Also Read – EAM Jaishankar calls on European Parliament President David Sassoli Advertise With Us As Prime Minister Narendra Modi takes charge of his new term, he must renew his commitment to addressing this climate emergency. It is essential that the Indian economy provides an ambitious and viable pathway to a net-zero carbon economy by 2050 at the latest. Encouragingly, business in India, and globally, are taking action on the climate.By cutting greenhouse gas emissions in line with the Paris Agreement goals, businesses are helping to fight climate change and reduce air pollution. Also Read – This is why Denmark, Sweden and Germany are considering a meat tax Advertise With Us India is moving into a strong position to lead globally as an early mover – having already overtaken the US to become the second largest solar power market in the world in terms of solar installations. In 2017, new solar installations reached a record 9.6 GW during the year, increasing employment in solar PV by 36 per cent to 1,64,400 jobs, according to IRENA (International Renewable Energy Agency). Advertise With Us India had the world’s fifth-largest additions to wind capacity in 2017, employing some 60,500 people. India’s clean energy sector could create 300,000 new jobs by 2020, already matching the current level of employment at Coal India Ltd. Investments in renewables in India topped those of fossil fuels for the first time in 2018. For a country that still relies on coal for more than half of its power needs, this is a strong signal that investors are embracing the zero-carbon future. India has set its sights high with ambitious renewable energy targets. Thanks to rapidly falling technology costs and supportive policies, the country is on track to achieve those goals years ahead of schedule. Moody’s forecasts that India will overachieve against its targets, with non-fossil fuel power generation capacity hitting 45 per cent (rather than 40 per cent) by 2022 along with a fall to 57 per cent of coal-fired power generation by 2030. India must tackle the legacy of fossil-fuel power production by committing to no new coal-fired power and planning the phasing out existing coal in a way that takes care of workers and ensures energy access and reliability for all. This would both accelerate the transition to a clean energy future and avoid stranded assets in years to come. It’s notable that Carbon Tracker has warned that some USD 60 billion of coal-fired power generation assets may be stranded in South-East Asia in the next decade. Business is signalling its support of a move away from coal. Tata Power’s decision to not build new coal plants is one such signal – with the company’s Mundra coal-fired power plant, one of the biggest in India, experiencing losses reaching USD 191 million for the first three-quarters of 2018-19. Tata Power’s latest plan includes a goal for up to 70 per cent of new capacity to come from solar, wind and hydro through to 2025. India’s thermal power giant NTPC Ltd has also reportedly shelved 10.5 GW of its planned coal-fired power projects year-to-date and the national coal-fired pre-construction project pipeline has shrunk by a quarter in the last six months according to the Global Coal Plant Tracker (GCPT). India is becoming a global leader in renewable energy. Now is the time for the Indian government to update its targets on climate and give the business the clarity and confidence needed to continue to unlock innovation and drive investment in zero carbon products and solutions. This is India’s moment to step up as a world leader, demonstrating how an economy can continue to grow and thrive with a clear pathway towards a cleaner, healthier zero-carbon future. (Damandeep Singh is Director of the India office of the Britain-based Carbon Disclosure Project (CDP) that supports companies and cities to disclose the environmental impact of major corporations)
Get Used to ‘Fortnite’s’ Powerful Mech SuitsRobots to Compete in Underground Challenge in Mining Tunnels Meet the new “garbage collector” of the sea: A new crab robot, designed to sample the waters looking for microplastics polluting the ocean, made its first dive on Saturday, World Oceans Day, in the sea off the Italian coast.The Crab Robot SILVER 2 (Seabed-Interaction Legged Vehicle for Exploration and Research 2), a robot explorer of the seabed created by the Institute of Robotics of the Scuola Superiore Sant’Anna di Pisa, supported by National Geographic Society and Arbi Dario Spa, was deployed off the Meloria shoal, in the Ligurian sea.The Crab Robot will adopt an arm that collects bags, bottles and other forms of plastic pollution in the sea. (Photo Credit: Laura Lezza / Getty Images)Soon, the robot will be equipped with an arm that collects plastic bags, bottles, and other forms of plastic pollution.The crab robot has the ability to move, walk, and run on the seabed. The six agile, crab-like legs allow the robot to adapt to the changing seabed soil, bounce on the ground without causing damage, and circumvent obstacles.“This bio-inspired robot can hop and jump in broader areas through a spring-loaded mechanism,” project scientific coordinator Marcello Calisti told Sant’Anna di Pisa magazine.“The spring has a simple structure, energy storage and release, and simple control so the robot can jump through an instantaneous contraction of the spring. The crab-like legs include ankle joints which have good jump performance. Our experiments show that the robot can achieve a smooth jump. Long-exposure images without background blurring demonstrate stability.”The robot is capable of adapting to the changing seabed soil. (Photo Credit: Laura Lezza / Getty Images)Callisti believes the robot can also help provide improved tools for researchers, due to its use of “legged locomotion to move dexterously on the seafloor, anchor to underwater structures, and gently interact with the environment.”A recent UN report has for called for urgent action to curb the flow of the 8 million tons of plastic pollution going into oceans each year.Many plastic particles are swallowed by farm animals or fish who mistake them for food, and thus can find their way onto our dinner plates, the UN said.They’ve also been found in a majority of the world’s tap water. By clogging sewers and providing breeding grounds for mosquitoes and pests, plastic waste — especially plastic bags — can increase the transmission of vector-borne diseases like malaria.While the issue has received increased attention in recent years, there is still no global agreement to tackle marine litter.Watch: Your Biodegradable Bag Might Not Degrade as Fast as You’d ThinkMore on Geek.com:Humans Consume More Than 70,000 Plastic Particles a YearDead Whale Found With More Than 80 Pounds of Plastic Bags in Its StomachTexas Coast Has More Ocean Trash Than Any Other Gulf State, Study Says Stay on target
Explore further Journal information: Nature (Phys.org)—Two teams of researchers have been looking into the ways that toxins can fool cell membranes into gaining access, thereby allowing for human ailments such as cholera. One team describes a pathway that is independent of the clathrin protein while the second team shows that such a pathway can be hijacked by toxins such as the bacteria responsible for cholera. Both teams have published their findings in the journal Nature. More information: Endophilin-A2 functions in membrane scission in clathrin-independent endocytosis, Nature (2014) DOI: 10.1038/nature14064AbstractDuring endocytosis, energy is invested to narrow the necks of cargo-containing plasma membrane invaginations to radii at which the opposing segments spontaneously coalesce, thereby leading to the detachment by scission of endocytic uptake carriers. In the clathrin pathway, dynamin uses mechanical energy from GTP hydrolysis to this effect, assisted by the BIN/amphiphysin/Rvs (BAR) domain-containing protein endophilin. Clathrin-independent endocytic events are often less reliant on dynamin, and whether in these cases BAR domain proteins such as endophilin contribute to scission has remained unexplored. Here we show, in human and other mammalian cell lines, that endophilin-A2 (endoA2) specifically and functionally associates with very early uptake structures that are induced by the bacterial Shiga and cholera toxins, which are both clathrin-independent endocytic cargoes. In controlled in vitro systems, endoA2 reshapes membranes before scission. Furthermore, we demonstrate that endoA2, dynamin and actin contribute in parallel to the scission of Shiga-toxin-induced tubules. Our results establish a novel function of endoA2 in clathrin-independent endocytosis. They document that distinct scission factors operate in an additive manner, and predict that specificity within a given uptake process arises from defined combinations of universal modules. Our findings highlight a previously unnoticed link between membrane scaffolding by endoA2 and pulling-force-driven dynamic scission. Mitosis mystery solved as role of key protein is confirmed EndoA2 localization to endocytic pathways. Credit: Nature (2014) doi:10.1038/nature14064 This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. One of the ways our bodies try to keep us healthy is by maintaining a plasma membrane around every one of our cells—the membrane’s job is to keep out harmful substances while allowing those that are beneficial to pass through—no easy feat. One of the ways the membrane does this job is through a protein called clathrin—the process by which it does so, under normal conditions, is called clathrin-mediated endocytosis (CME). In this new effort, one team has found that there is a clathrin independent process whereby proteins are allowed to enter cells—they’ve named it fast endophilin-mediated endocytosis (FEME), while the other team has found that some bacteria are able to take advantage of this process to create channels to get inside cells and cause problems.FEME, the first team found, appears to be triggered by membrane-bound receptor proteins or by bacterial toxins. The molecules in the protein appear to be converted to a form that is able to attract the endophilin protein which causes the membrane to invaginate into tubules which eventually form into visicles containing proteins or worse toxins. The second team found that the process involves endophylin, dynamin and actin proteins, in ways that allow the channel to come into existence, suggesting that some bacteria may even drive the process.These findings by the two teams suggest there are pathways into our cells that scientists still don’t understand and also provide avenues for additional studies in a variety of ways—such as looking into how bacteria are able to recruit endophilin in either FEME or CME and whether there are substances that might prevent it from happening in the first, place, bolstering the cell membrane defenses that are trying to keep us healthy. Citation: Studies show a pathway for imported proteins through cell membrane that can be hijacked by toxins (2014, December 18) retrieved 18 August 2019 from https://phys.org/news/2014-12-pathway-imported-proteins-cell-membrane.html © 2014 Phys.org
Kolkata: The first Primary Health Centre (PHC) in New Town will be opened shortly.The centre will be manned by a specialised doctor and the facility will be expanded over a period of time. It may be mentioned that New Town is coming up as a medical hub and many private players have set up their hospitals and medical centres in the area. They are also treating every type of disease including cancer. However, the need for setting up a state-run institution was urgently felt as a part of the expansion of the net of state-run health establishments. Also Read – Bose & Gandhi: More similar than apart, says Sugata BoseIt may be recalled that availing treatment in a state-run medical establishment in Bengal has become completely free. Chief Minister Mamata Banerjee has also said that to get the best quality treatment, people from neighbouring states and countries are coming to Bengal. Bengal is the only state in the country where heart transplantation and kidney transplantation are done free of cost in the state-run hospitals. In this backdrop, the PHC in New Town is also expected to provide quality treatment to the patients, free of cost.
Disclosure: Our goal is to feature products and services that we think you’ll find interesting and useful. If you purchase them, Entrepreneur may get a small share of the revenue from the sale from our commerce partners. August 5, 2019 2 min read Listen Now Problem Solvers with Jason Feifer Posters. Flyers. Logos. Brochures. Gift certificates. Instagram ads. These are just some of the designs you need to market a business. And if you want to stand out from competitors and catch the eye of your target audience, they’d better be impressive.Good design converts, and if you want to be armed with visual techniques that drive sales, the Ultimate Graphic Design Bootcamp Certification Bundle comes packed with over 18 hours of training to help you master the techniques of graphic design. You can pick it up on sale for 96% off.Across five comprehensive courses, this online course bundle will give you a clearer understanding of the foundations and principles of graphic design. You will get to grips with what makes a design stand out, which will then help you create at a higher level (and score the job or promotion you’ve been eyeing). You’ll also learn how to navigate and create projects using the big three design apps — Photoshop, Illustrator, and InDesign — as well as get familiarized with the tested and proven design techniques needed to create pixel-perfect projects for print and web.Usually $925, the Ultimate Graphic Design Bootcamp Certification Bundle is on sale now for $29 — a savings of 96 percent. Hear from business owners and CEOs who went through a crippling business problem and came out the other side bigger and stronger.
Facebook Comments Agents from Costa Rica’s Judicial Investigation Police on Thursday morning arrested three employees of the BAC San José branch in Quepos, a port town next to the popular central Pacific tourist destination of Manuel Antonio, on suspicion of money laundering. A fourth suspect, believed to be the ringleader of the operation, is still at large, according to law enforcement sources.The suspects, surnamed Rivera Quiros, Centeno Pérez and Pereza Jiménez, are accused of exchanging up to $160,000 in small, daily increments into colones and either delivering the cash to the fourth suspect, or depositing it into a bank account under another name. Sources say the group allegedly exchanged between $4,000 and $6,000 a day in order to avoid being flagged by banking laws for amounts over $10,000. According to investigators, the bank employees – including a boss at the BAC San José branch – allegedly received commissions on each transaction. The investigation is ongoing. Related posts:Leaked bank files show HSBC ‘helped clients dodge taxes’ Costa Rica’s Solís authorizes strategy to fight money laundering, terrorism financing Costa Rica homicide rate hits record high Costa Ricans report increasing safety concerns; 2016 is set to become most violent year on record